Arsenic trioxide is used as an antineoplastic agent in promyelocytic leukemia. Arsenic is a deadly poison identified as the cause of acute poisoning in suicide, homicide, and accidents. The pent valent form is metabolized by reduction into the trivalent form, followed by . Arsenic Trioxide (As 2 O 3, CAS#: 1327-53-3): toxic glassy, amorphous lumps or crystal compound; slightly soluble in water; octahedral crystals change to the monoclinic form by heating at 200C; arsenious acid; occurs naturally as arsenolite and claudetite; used in some medicinal preparations but in . Trivalent arsenic, better known as arsenic trioxide, is the active ingredient in Trisenox at a concentration of 1.0 mg/mL. The water solubility of arsenic salts varies depending on the salt. We report two cases of acute poisoning with an unwettable formulation of arsenic trioxide. . Arsenic trioxide is used as an antineoplastic agent in promyelocytic leukemia. AEGL-1 values are not proposed, because there were no human or animal data available relating to AEGL-1 endpoints for arsenic trioxide. . Inorganic arsenic is generally more toxic than organic arsenic. It was cheap and was a perfectly normal addition to any shopping list. In a detailed independent review of 1000 electrocardiograms from 99 patients on clinical trials, 26 . Arsenic Trioxide is an odorless, colorless to white crystal or powder. As III is 60 times more toxic than As V. Organic arsenic is non-toxic whereas inorganic arsenic is toxic. When exposed to this toxin, we can get all sorts of symptoms and health problems. Arsenic is a deadly poison identified as the cause of acute poisoning in suicide, homicide, and accidents. Arsenic-based chemotherapy drugs, such as arsenic trioxide, are already in use for some cancers. Arsenic is used to manufacture weed killers and insecticides. Very toxic chemicals, or those that are reproductive hazards or sensitizers, require expert advice on control measures if a less toxic chemical cannot be substituted. It affects the digestive system when eaten. It is highly toxic in its inorganic form. Arsenic trioxide is used as an antineoplastic agent in promyelocytic leukemia.1., 2., 3. Drug type: Arsenic Trioxide is an anti-cancer ("antineoplastic" or "cytotoxic") chemotherapy drug. 3 Kwong YL, Todd D. Delicious poison: arsenic . It was very cheap, a by-product of metal industries, and ordinary Victorians could buy it from their local chemist, or even their grocer, as poison for rats and mice. Arsenic trioxide can cause a serious heart problem. Consult an oncologist, medical toxicologist and/or poison center for assistance in managing patients with overdose. Definition from the NCI Drug Dictionary - Detailed scientific definition and other names for this drug. Its mechanisms include regulation of apoptosis and autophagy; promotion of the intracellular production of reactive oxygen species, causing oxidative damage; and inhibition of tumor stem cells. Although arsenic homicides commonly receive media publicity, the primary source of arsenic toxicity to the general population is by contaminated water, soil and food products. elemental metallic arsenic - insoluble in water or body fluids and may not be poisonous, but when heated to high temperatures may become the highly toxic form, arsenic trioxide 1; arsenic trisulfide (orpiment) - low toxicity due to minimal solubility, but reported dose-dependent reactions (22541879 J Emerg Med 2013 Feb;44(2):367) It also can be toxic if on the skin for long amounts of time. Even dilute solutions of arsenic trioxide are dangerous on contact with the eyes. PDF | Arsenic trioxide (As2O3) has been used medicinally for thousands of years. Though a poison, arsenic trioxide is also used in cancer treatments. Arsenic is extremely poisonous to humans. [17] [18] [19] Chronic arsenic poisoning is known as arsenicosis. After the operation, he developed ventricular fibrillation. The brilliant hue of this green pigment, which was used to colour dresses and hair ornaments, was achieved by mixing copper and highly toxic arsenic trioxide or "white arsenic" as it was known. Arsenic trioxide is the generic name for the trade name drug Trisenox. Arsenic trioxide poisoning: a description of two acute overdoses Arsenic is a traditional poison that has a history extending back into ancient times, as a medicinal agent, a homicidal poison and more recently in deliberate and unintentional self-poisoning. Specifically, the risk for agranulocytosis and pancytopenia . To date, only 3 cases of Q-T prolongation above 500 millisecond (ms) have been reported. Today, an injectable drug made with arsenic trioxide utilizes arsenic's destructive power to target leukemia cancer cells. Arsenic is a naturally occurring element with a reputation as "king of poisons" as well as the "poison of kings." Skip to main content . Arsenic is considered to be a heavy metal, and arsenic toxicity shares some similarities with poisonings by other heavy metals. Show More Overview Uses Side Effects Precautions Interactions Dosing Reviews (5) Overview Arsenic is a trace element. Section 4 - First Aid Measures Eyes: What most people mean by arsenic is the compound arsenic trioxide, known in the 1800s as white arsenic. same application with arsenic trioxide. Arsenic Trioxide, As 2 O 3, is the most frequently found Arsenic compound. Inorganic arsenic is generally more toxic than organic arsenic. Arsenic toxicity inactivates up to 200 enzymes, most notably those involved in cellular energy pathways and DNA replication and repair, and is substituted for phosphate in high energy compounds such as ATP. Arsenic is an element that is a potent, toxic carcinogen. It's not understood exactly how it . Recent studies have shown one form of seaweed, hijiki, to contain high levels of inorganic arsenic [Rose et al. This is an early exampl. An effect on glioma has also been shown. Forms of arsenic that are more rapidly absorbed are more toxic, while those most rapidly eliminated. In the 1990s, researchers from China showed complete clinical remissions in two-thirds of patients with acute promyelocytic leukemia (APL) treated with arsenic, and a survival rate of 60% at 7 years. Arsenic is combined with other elements such as oxygen, chlorine, and sulfur to form inorganic arsenic compounds. People are exposed to elevated levels of inorganic arsenic through drinking contaminated water, using contaminated water in food preparation and irrigation of food crops . Arsenic exists in four common valence states. Arsenic trioxide is used as an antineoplastic agent in promyelocytic leukemia. loss of appetite mood changes muscle pain or cramps nausea numbness or tingling in hands, feet, or lips seizures sore throat trouble breathing unusual tiredness or weakness vomiting Less common Black, tarry stools bluish lips or skin blurred vision chest pain dizziness or lightheadedness fever flushed, dry skin fruit-like breath odor nic trioxide | \ rs-nik-, -n-ik- \ Medical Definition of arsenic trioxide : a poisonous trioxide of arsenic As2O3 or As4O6 that is administered intravenously to treat some forms of leukemia and in minute doses is used as a homeopathic remedy A harmless-looking powder, resembling flour or sugar at a quick glance, white arsenic is virtually undetectable in hot food and drink and fatal in small doses. Control measures Arsenic trioxide (an odorless, tasteless, white or transparent, nonflammable solid) is one of the most toxic and prevalent forms of arsenic. Toxicity from natural sources of arsenic is rare except from . Arsenic is a deadly poison identified as the cause of acute poisoning in suicide, homicide, and accidents. [1] It was used throughout history as a potent poison to kill off kings and emperors and facilitate rich inheritances. Chemical name : diarsenic trioxide, arsenic trioxide CAS No : 1327-53-3 Product code : LC11505 Formula : As2O3 Synonyms : Arsenous acid / Arseni c (III) oxide / Diarsenic trioxide . . Arsenic trioxide has shown a strong anti-tumor effect with little toxicity when used in the treatment of acute promyelocytic leukemia (APL). However, toxic effects resolved with temporary discontinuation of either arsenic trioxide, ATRA or both. MedlinePlus Information on Arsenic Trioxide - A lay language summary of important information about this drug that may include the . Arsenic (As) is a nearly tasteless . This drug is formulated as a sterile, injectable solution of arsenic trioxide. It is very toxic and can enter the biological system through contaminated water, soil and air. Arsenic poisoning is a global health issue affecting millions of people worldwide through environmental and occupational exposure, as well as intentional suicide and homicide attempts. Arsenobetaine and Arsenocholine are the organic forms known as "fish arsenic" and are relatively nontoxic to humans. It is used to make other Arsenic compounds, in . DOI: 10.1007/s12012-018-09504-7 Abstract Arsenic trioxide (ATO) is among the first-line chemotherapeutic drugs used in oncological practice. Includes Arsenic Trioxide indications, dosage/administration, pharmacology, mechanism/onset/duration of action, half-life, dosage forms, interactions, warnings, adverse reactions, off-label uses and more. OTHER NAME(S): Arsenate, Arsenic Pentoxide, Arsenic Trichloride, . Dipyrone: May enhance the adverse/toxic effect of Myelosuppressive Agents. Humans have exploited its toxic properties in weed killers, fungicides and insecticides, especially in vineyards, apple orchards, and cotton and tobacco fields. Chronic exposure to arsenical dust may cause shortness of breath, nausea, chest pains, and garlic odor. Arsenic as a pure element would not be as poisonous as it cannot be absorbed by the human body in significant amounts. ----- 3 Ecological Characteristics: Arsenic trioxide is moderately toxic to birds, slightly toxic to fish and moderately toxic to aquatic invertebrate species. It has shown substantial efficacy in treating patients with relapsed or refractory acute promyelocytic leukaemia. Arsenic itself is not poisonous; it is the compounds of arsenic, particularly arsenous oxide or arsenic trioxide (sankhya or somalkhar) and various arsenites of Cu, Na and K that are toxic to the humans. The first evidence of the efficacy of arsenic in leukemia was reported in 1882. The organic forms of arsenic found in seafood (mainly arsenobetaine and arsenocholine, also referred to as "fish arsenic") are generally considered to be nontoxic, and are excreted in urine within 48 hours of ingestion [ATSDR 2007]. Arsenic trioxide is highly toxic when eaten. It tarnishes rapidly in air, and at high temperatures burns forming a white cloud of arsenic trioxide. Arsenic trioxide is used as an antineoplastic agent in promyelocytic leukemia. arsenic trioxide is a very effective drug used to treat . Historically, arsenic was known as both the "king of poisons" and the "poison of kings," for its toxic power and its popularity among rulers who wanted to quietly do away with their rivals . Arsine gas is the most toxic arsenical (acute exposure). Arsenic pentoxide is formed by the action of an oxidizing agent (e.g., nitric acid) on arsenious oxide. . OSHA has set an "action level" of 5 mcg/m . Workers exposed to arsenic trioxide fumes in their job can be poisoned as well. As little as 1-2.5 mg/kg of arsenic trioxide is a potentially fatal dose. Your risk may be higher if you also use certain other medicines for infections, asthma, heart problems, high blood pressure, depression, mental illness, cancer, malaria, or HIV. . Ecology - water : Toxic to aquatic life. It is ubiquitous in our environment and it is a potent neurological and liver toxin as well as a lung, bladder and skin carcinogen. Q-T prolongation is a well known and expected effect of arsenic trioxide treatment. While arsenic is. arsenic trioxide, leukemia, poisons To the Editor: Lately, arsenic trioxide (As 2 O 3 ) has been described in the treatment of acute myeloid leukemia. The poisonous properties are well known and the subject of an extensive literature. In addition, some medicines, used to cure certain . Arsine (AsH 3), a colourless poisonous gas composed of arsenic and hydrogen, is another familiar arsenic compound. n. A poisonous, white amorphous powder, As2O3, used in insecticides, rat poisons, weed killers, pigments, and preservatives for hides and wood. Arsenic trioxide, sold under the brand name Trisenox among others, is an inorganic compound and medication. Arsenic - more properly arsenic trioxide - is a highly poisonous white powder. What is arsenic? nausea, vomiting, abdominal pain, diarrhea, dark urine, and. Toxicity from natural sources of arsenic is rare except from . Arsenic trioxide is used today as a treatment for some types of leukaemia, and is given intravenously as a low concentration solution due to its toxicity. 1., 2., 3. A total gastrectomy was also performed to avoid intestinal perforation and arsenic poisoning. When arsenic is being referred to as a poison, it is 'white arsenic' or arsenic trioxide, or any of the other poisonous compounds of arsenic being talked about. Persistence and degradability . 4) TRANSFER CRITERIA: Patients with large overdoses or severe . As little as 1-2.5 mg/kg of arsenic trioxide is a potentially fatal dose. The relative risk of emerald green bookcloth "depends on. At the same time, it was shown that arsenic trioxide (As 2 O 3 . Arsenic trioxide (As 2 O 3 /As 4 O 6) is a white, odorless powder of low aqueous solubility. dehydration. Home; Frequently Asked Questions; . Related pages[ change | change source] Bismuth trioxide Antimony trioxide arsenic trioxide synonyms, arsenic trioxide pronunciation, arsenic trioxide translation, English dictionary definition of arsenic trioxide. Arsenious oxide, commonly known as white arsenic, is obtained as a by-product from the roasting of the ores of copper, lead, and certain other metals as well as by the roasting of arsenopyrite and arsenic sulfide ores.. Is arsenic trioxide a poison? Arsenic poisoning is a medical condition that occurs due to elevated levels of arsenic in the body. Define arsenic trioxide. Top of Page Key Points Arsenic is an element and is a naturally occurring mineral found widely in the environment. Abstract In a suicide attempt, a 54-year-old man ingested arsenic trioxide. The drug's manufacturer specifically warns that only .
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